Pharmacologic considerations in the treatment of ...

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Title Pharmacologic considerations in the treatment of neonatal septicemia and its complications
Author(s) Maureen Wichtel, E. Buys, J. DeLuca, G. Stringel
Journal The Veterinary Clinics of North America. Equine Practice
Date 1999
Volume 15
Issue 3
Start page 725
End page 746
Abstract This article focuses on the pharmacologic properties of drugs commonly used in the treatment of neonatal septicemia and its complications. Rational therapy demands an awareness of not only the pharmacology of individual drugs but also the interactions and anticipated fate of such drugs in the rapidly changing physiologic environment of the neonate. Further research in the area of equine neonatal pharmacology should greatly assist our understanding of the impact of the disease state on the unique physiology of the newborn and should allow us to better predict the ultimate fate of drugs commonly used for such purposes. Careful dosing and close monitoring of pharmacologic effects are critical for a successful outcome. In the future, newer therapeutic strategies that are safe and efficacious may provide a means to circumvent many of the problems currently encountered with treating the septicemic newborn foal.

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