Pituitary corticotroph macrotumors. Diagnosis and ...



Title Pituitary corticotroph macrotumors. Diagnosis and treatment
Author(s) Sherri L. Ihle
Journal The Veterinary Clinics of North America. Small Animal Practice
Date 1997
Volume 27
Issue 2
Start page 287
End page 297
Abstract Pituitary corticotroph macrotumors occur in 10% to 50% of dogs with PDH. Clinical signs may be only those of hypercortisolism or may include neurologic signs such as stupor, inappetance, circling, or pacing. Currently, CT and MRI are the only tests that can confirm the presence of a pituitary macrotumor in these patients. Results of endocrine testing are not significantly different from those of dogs with a microtumor. When a macroscopic pituitary tumor is identified in a dog with neurologic signs, or if a larger tumor is found in a dog even in the absence of neurologic signs, radiation therapy is currently the treatment of choice. Unfortunately, success rates with treatment are variable. A better response may be seen if the tumor is smaller and neurologic signs are minimal or absent at the time of treatment.

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