Prednisone treatment alters the serum amylase and ...

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Title Prednisone treatment alters the serum amylase and lipase activities in normal dogs without causing pancreatitis
Author(s) C. Fittschen, James E. C. Bellamy
Journal Canadian Journal of Comparative Medicine. Revue Canadienne de Medecine Comparee
Date 1984
Volume 48
Issue 2
Start page 136
End page 140
Abstract In order to test the hypothesis that treatment with glucocorticoids causes pancreatitis in dogs, 18 mongrel dogs were divided into three groups of six individuals, each group receiving prednisone at different doses orally or intramuscularly for two weeks. Two groups consisting of six dogs each served as controls. Treatment for two weeks with oral prednisone at 1.2 mg/kg body weight or at 4 mg/kg body weight daily decreased the serum amylase activities, but increased the serum lipase activities. Postmortem examinations revealed microscopic evidence of mild pancreatitis in only one dog given prednisone, that clinically appeared normal. It was concluded that daily doses of 4 mg prednisone/kg body weight or less given orally or intramuscularly for two weeks do not cause pancreatitis in dogs.

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