Role of the chancre in induction of immunity to ...

Description

Citation

Title Role of the chancre in induction of immunity to tsetse-transmitted Trypanosoma (Nannomonas) congolense in goats
Author(s) V. O. Taiwo, V. M. Nantulya, S. K. Moloo, B. O. Ikede
Journal Veterinary Immunology and Immunopathology
Date 1990
Volume 26
Issue 1
Start page 59
End page 70
Abstract Local skin reactions (chancres) developed in goats at the sites of deposition, by tsetse flies, of metacyclics of Trypanosoma congolense. The chancres developed much faster and were more pronounced when ten infected tsetse were allowed to feed on a spot as compared to only one fly per spot. The initial host cellular reaction in the chancre was predominantly polymorphonuclear, followed at the peak of development of the chancre by a predominantly lymphoblastic and plasmacytic reaction. Trypanosomes were found in various stages of division as well as degeneration in chancre biopsies taken at various days post-infection (p.i.). Most of the trypanosomes recovered from the chancre tissue fluid were found to bear the same variable surface glycoprotein (VSG) epitopes as the corresponding metacyclics for as long as 13 days p.i., as revealed by indirect immunofluorescence using mouse anti-metacyclic VSG hyperimmune sera and monoclonal antibodies. Immunization of goats with metacyclic trypanosomes, by exposure to infected tsetse bites followed by treatment of the infected goats on day 13 p.i., gave rise to the development of protection to homologous tsetse-transmitted challenge, whilst immunization by intravenous inoculation of the metacyclics did not induce such protection. Chancre formation would thus appear to be vital for the induction of comprehensive immune recognition of the metacyclic variable antigen repertoire deposited in the skin by infected tsetse, and hence development of protective immunity.

Using APA 6th Edition citation style.

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]

Times viewed: 203

Adding this citation to "My List" will allow you to export this citation in other styles.