Interaction between Pasteurella haemolytica and ...
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| Title | Interaction between Pasteurella haemolytica and bovine alveolar macrophages: cytotoxic effect on macrophages and impaired phagocytosis |
| Author(s) | R. Markham, B. Wilkie |
| Journal | American Journal of Veterinary Research |
| Date | 1980 |
| Volume | 41 |
| Issue | 1 |
| Start page | 18 |
| End page | 22 |
| Abstract | Cultured bovine alveolar macrophages phagocytosed formalized 125I-labeled Pasteurella haemolytica organisms poorly when compared with uptake of an identical number of radiolabeled Yersinia enterocolitica organisms. The presence of immune serum enhanced uptake of P haemolytica, yet at high bacteria-to-macrophage ratios, a significant positive correlation existed between uptake and loss of cells from coverslips. This phenomenon was not observed with Y enterocolitica. While culture supernatant from P haemolytica either impaired phagocytosis or were cytotoxic to cultured macrophages, supernatant from Y enterocolitica did not show this effect. The observation of an apparent deterimental effect on bovine alveolar macrophages after uptake of P haemolytica may be used to explain events occurring in pneumonic pasteurellosis in cattle and may help in the development of immunizaiton techniques. |
| ISSN | 0002-9645 |
Using APA 6th Edition citation style.
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