Multipoint linkage of 9 anonymous probes to HPRT, ...



Title Multipoint linkage of 9 anonymous probes to HPRT, factor 9, and fragile X
Author(s) W. T. Brown, W. Ye, A. C. Gross, Catherine B. Chan, C. S. Dobkin, E. C. Jenkins
Journal American Journal of Medical Genetics
Date 1988
Volume 30
Issue 1-2
Start page 551
End page 566
Abstract We have analyzed the segregation of restriction fragment length polymorphisms (RFLPs) associated with 9 anonymous probes detecting loci DXS10, DXS15, DXS19, DXS37, DXS51, DXS52, DXS98, DXS99, and DXS100 and probes for HPRT and F9 in a set of 40 families segregating fragile X (fra(X]. Using two-point and multipoint analysis, we have established their relative genetic locations. The results indicate that DXS99 and DXS10, unlike previous reports, are not tightly linked to F9. A new locus was found to map within the F9 - fra(X) region. DXS98 showed 6% recombination with fra(X) and appeared to be the closest locus to fra(X). These results will be useful for mapping the relative position of newly defined X probes in this region and for future genetic studies of families with fra(X), hemophilia B, or Lesch-Nyhan mutations.

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