lin-31, a Caenorhabditis elegans HNF-3/fork head ...



Title lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulva development
Author(s) Lisa M. Miller, M. E. Gallegos, B. A. Morisseau, S. K. Kim
Journal Genes and Development
Date 1993
Volume 7
Issue 6
Start page 933
End page 947
Abstract Late events in the cell-cell signalling pathway that controls the specification of vulva cell fates in C. elegans are characterized. The lin-31 gene acts downstream of the ras homolog let-60 and encodes a member of the HNF-3/fork head family of DNA-binding transcription factors. lin-31 regulates how vulval precursor cells choose their fate and in lin-31 mutants, these cells do not properly choose which fate to express and therefore adopt any of the 3 possible vulval cell fates in a deregulated manner..

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