Effects of corticosteroid treatment on survival time ...

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Title Effects of corticosteroid treatment on survival time in dogs with chronic hepatitis: 151 cases (1977-1985)
Author(s) D. R. Strombeck, Lisa M. Miller, D. Harrold
Journal Journal of the American Veterinary Medical Association
Date 1988
Volume 193
Issue 9
Start page 1109
End page 1113
Abstract Medical records of 151 dogs with chronic hepatitis were reviewed. Corticosteroid treatment had a significant effect on improving survival time when corticosteroid-treated dogs were compared with untreated dogs. Dogs dying within 1 week of examination represented 37.1% of the cases, and when compared with those living more than 1 week, serum glucose concentration was significantly lower, prothrombin time and partial thromboplastin time were significantly longer; blood ammonium chloride was significantly higher and necrosis severity and fibrosis severity were significantly greater. The best predictors of early death were low normal serum glucose concentration and prolonged prothrombin time, which was abnormal in 60% of dogs dying early. Partial thromboplastin time, which was increased in 92% of dogs dying early and in 42.6% of dogs living more than 1 week, was a less reliable predictor. Plasma ammonia concentration after oral administration of NH4Cl was least reliable in predicting early death. In dogs living more than 1 week, hypoalbuminaemia was a predictor of shorter survival time. Of all the histological features evaluated, only necrosis severity and fibrosis severity were accurate predictors of early death. The presence of bridging fibrosis was a predictor of shorter survival time in dogs living more than 1 week..

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