Clinical response and antimicrobial residue test ...



Paper title Clinical response and antimicrobial residue test results in non-antibiotic treated cows with induced acute coliform mastitis
Paper author(s) H. R. Stampfli, J. Nemeth, k. Leslie, C. L. Gyles, C. A. Muckle
Proceedings title Proceedings-18th-World-Buiatrics-Congress: -26th-Congress-of-the-Italian-Association-of-Buiatrics,-Bologna,-Italy,-August-29-September-2,-1994
Date 1994
Conference F., Trenti
Abstract 14 early lactation Holstein cows were experimentally challenged by intramammary infusion of 2 teats to compare the virulence of the strains of Escherichia coli isolated from faeces or from cases of bovine mastitis. The initial treatment protocol consisted of parenteral antibiotics and fluid therapy with the onset of high fever, significant systemic signs and local inflammation. Two cows treated with this protocol developed severe depression, dehydration, recumbency and were killed. Subsequently, the treatment protocol was revised to commence stripping of the affected quarters plus injections of 30 IU of oxytocin once the body temperature was >=41 degrees C. This was repeated at 2 h intervals until the temperature was <=39.5 degrees C. All 12 cows treated with this protocol responded within 24 h. Bacteria were cleared from all infected quarters within 96 h. The presence of non-antibiotic inhibitory substances in milk of the infected and non-infected quarters was evaluated at 0, 12, 24, 36, 48, 72 and 96 h using the Brilliant Black Reductase Test (BRT), Delvotest P (DTP) and Bacillus stearothermophilus Disc Assay (BSDA) reside test. False positive results were found in at least one sample between 12 and 48 h after infection in 4, 5 and 7 cows using BRT, DTP and BSDA, respectively. It was concluded that non-antibiotic therapy involving stripping and oxytocin merits further study. In addition, acute coliform mastitis cases may represent a source of error in routine antibiotic residue testing programmes..
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