Electrocardiographic and cardiopulmonary effects of ...

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Title Electrocardiographic and cardiopulmonary effects of intramuscular administration of glycopyrrolate and romifidine in conscious Beagle dogs
Author(s) Kip A. Lemke
Journal Veterinary Anaesthesia and Analgesia
Date 2001
Volume 28
Issue 2
Start page 75
End page 86
Abstract The aim of this study was to determine the electrocardiographic and cardiopulmonary effects of IM administration of romifidine with and without prior administration of glycopyrrolate in conscious dogs. Twelve healthy, adult beagles. Materials and methods Dogs were assigned at random to each of three treatments with glycopyrrolate (six dogs), and to each of three treatments without glycopyrrolate (six dogs). Baseline data were recorded, and saline solution or glycopyrrolate (10 micro g kg-1) was given IM. After 15 minutes, saline solution (control) or romifidine (20 or 40 micro g kg-1) was given IM. An ECG, heart rate (HR), systemic blood pressures, and respiratory rate (RR) were recorded before and 2.5, 5, 10, 15, 30, 45, 60, 75, 90, 105 and 120 minutes after romifidine administration. Rectal temperature (RT), pH, PaCO2, PaO2, hematocrit and plasma protein were determined before and 15, 30, 60 and 120 minutes after romifidine administration. Data were analyzed using analysis of variance for repeated measures and Tukey multiple comparison tests. Without glycopyrrolate, HR (beats minute-1) decreased to minimum values (mean +or- SD) of 52 +or- 7 and 49 +or- 12 (control 89 +or- 20) 45 minutes after administration of romifidine at doses of 20 and 40 micro g kg-1, respectively. Sinus bradycardia (HR < 60 beats minute-1), which persisted for up to 120 minutes, was observed in five of six and six of six dogs given romifidine at doses of 20 and 40 micro g kg-1, respectively. With glycopyrrolate, decreases in HR were prevented and mean arterial pressure (mm Hg) increased to maximum values of 139 +or- 25 and 173 +or- 17 (control 113 +or- 11) 30 minutes after administration of romifidine at doses of 20 and 40 micro g kg-1, respectively. With and without glycopyrrolate, RR did not change appreciably, RT decreased, and pH, PaCO2, PaO2, hematocrit and plasma protein did not change after administration of romifidine. In healthy conscious beagles, IM administration of romifidine at doses of 20 and 40 micro g kg-1 causes sinus bradycardia which persists for up to 120 minutes. Administration of glycopyrrolate 15 minutes before administration of romifidine, prevents sinus bradycardia and induces moderate increases in arterial pressure..
DOI 10.1046/j.1467-2987.2000.00037.x

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