A lipopolysaccharide-specific bacteriophage for ...



Title A lipopolysaccharide-specific bacteriophage for Aeromonas salmonicida
Author(s) E. E. Ishiguro, T. Ainsworth, Darcy H. Shaw, W. W. Kay, T. J. Trust
Journal Canadian Journal of Microbiology
Date 1983
Volume 29
Issue 10
Start page 1458
End page 1461
Abstract Cell wall lipopolysaccharide (LPS) was identified as the receptor for the A. salmonicida bacteriophage strain 55R-1. Mutants of A. salmonicida resistant to phage 55R-1 were unable to adsorb phage 55R-1 and were shown to be defective in LPS structure. Purified A. salmonicida LPS inactivated phage 55R-1, but the O-polysaccharide and the core oligosaccharide portions of the LPS were ineffective. These results suggest that lipid A was required for receptor activity. Antibodies directed against LPS also inhibited phage adsorption..

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