Oxidation of tyrosine diketopiperazine to DOPA ...



Title Oxidation of tyrosine diketopiperazine to DOPA diketopiperazine with tyrosine hydroxylase
Author(s) M. B. Saleh, Russell G. Kerr
Journal Journal of Natural Products
Date 2004
Volume 67
Issue 8
Start page 1390
End page 1391
Abstract The diketopiperazine of DOPA was synthesized in high yield from the diketopiperazine of tyrosine using PC12 cell lysate, which expresses high levels of tyrosine hydroxylase. This represents the first use of this enzyme to prepare DOPA-containing peptides.
DOI 10.1021/np034083j
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