Autophagy-dependent viral recognition by ...



Title Autophagy-dependent viral recognition by plasmacytoid dendritic cells
Author(s) H. K. Lee, J. M. Lund, Balaji Ramanathan, N. Mizushima, A. Iwasaki
Journal Science (New York, N.Y.)
Date 2007
Volume 315
Issue 5817
Start page 1398
End page 1401
Abstract Plasmacytoid dendritic cells (pDCs) detect viruses in the acidified endosomes by means of Toll-like receptors (TLRs). Yet, pDC responses to certain single-stranded RNA (ssRNA) viruses occur only after live viral infection. We present evidence here that the recognition of such viruses by TLR7 requires transport of cytosolic viral replication intermediates into the lysosome by the process of autophagy. In addition, autophagy was found to be required for the production of interferon-alpha by pDCs. These results support a key role for autophagy in mediating ssRNA virus detection and interferon-alpha secretion by pDCs and suggest that cytosolic replication intermediates of viruses serve as pathogen signatures recognized by TLR7.
DOI 10.1126/science.1136880

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