PR-39, a porcine antimicrobial peptide, inhibits ...

Description

Citation

Title PR-39, a porcine antimicrobial peptide, inhibits apoptosis: involvement of caspase-3
Author(s) Balaji Ramanathan, H. Wu, C. R. Ross, F. Blecha
Journal Developmental and Comparative Immunology
Date 2004
Volume 28
Issue 2
Start page 163
End page 169
Abstract The porcine antimicrobial peptide, PR-39, has several activities beyond its function of killing bacteria. Here we report that PR-39 alters macrophage viability by inhibiting apoptosis, which was induced by nutrient depletion, LPS stimulation or camptothecin treatment. This antiapoptotic effect was pronounced resulting in significant reductions in annexin-V binding to externalized phosphatidylserine and was associated with a decrease in caspase-3 activity. These findings suggest that PR-39, a porcine neutrophil-derived antimicrobial peptide, might function in the inflammatory milieu not only to kill bacteria, but also to aid in modulating the viability of inflammatory cells by regulating apoptosis.

Using APA 6th Edition citation style.

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]

Times viewed: 202

Adding this citation to "My List" will allow you to export this citation in other styles.