Alteration of primate ovary surface epithelium by ...



Title Alteration of primate ovary surface epithelium by exposure to hexachlorobenzene: a quantitative study
Author(s) David E. Sims, A. Singh, A. Donald, J. Jarrell, D. C. Villeneuve
Journal Histology and Histopathology
Date 1991
Volume 6
Issue 4
Start page 525
End page 529
Abstract Hexachlorobenzene (HCB) is a fungicide and a pollutant of increasing concern in industrialized regions of the world. Reproductive failure is one of the effects of HCB upon mammals. Alteration of cell shape in the ovary surface epithelium (OSE) of Cynomolgus monkeys following oral administration of HCB was observed in this study. At the lowest dose used, 0.1 mg/kg body weight, a dosage that is associated with follicular degeneration, HCB caused quantifiable changes in length-to-width ratios of OSE. Measurement of cell shape by light microscopy offers a reliable indication of OSE changes induced by HCB.

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