Only through the brain nuclei, arginine vasopressin ...



Title Only through the brain nuclei, arginine vasopressin regulates antinociception in the rat
Author(s) J. Yang, C. Y. Song, W. Y. Liu, C. Song, B. C. Lin
Journal Peptides
Date 2005
Abstract The effect of arginine vasopressin (AVP) on rat antinociception was investigated. Intraventricular injection of 50 or 100ng AVP dose-dependently increased the pain threshold; In contrast, intraventricular injection of 10mul anti-AVP serum decreased the threshold; both intrathecal injection of 200ng AVP or 10mul anti-AVP serum and intravenous injection of 5mug AVP or 200mul anti-AVP serum did not influence the pain threshold; pain stimulation reduced the AVP contents in hypothalamic paraventricular nucleus (PVH), and elevated the AVP contents in hypothalamic supraoptical nucleus (SON) and periaqueductal gray (PAG), but no change in AVP contents was detected in pituitary, spinal cord and serum. The results indicated that AVP regulation of antinociception was limited to the brain nuclei.
DOI 10.1016/j.peptides.2005.06.007

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