Changes in substance P and 5-HT binding in the ...



Title Changes in substance P and 5-HT binding in the spinal cord dorsal horn and lamina 10 after dorsolateral funiculus lesions
Author(s) N. A. Bernau, Susan D. Dawson, L. A. Kane, L. M. Pubols
Journal Brain Research
Date 1993
Volume 613
Issue 1
Start page 106
End page 114
Abstract The present study was undertaken to determine whether changes in receptor binding of substance P (SP) and 5-hydroxytryptamine (5-HT) occur in lumbar spinal cord laminae 2, 3, 4 and 10 following interruption of descending SP and 5-HT input. These transmitters and spinal cord regions have been implicated in nociceptive and visceral functions. Quantitative receptor binding autoradiography was used to assess the binding of 2 nM [3H]SP and 2 nM [3H]5-HT to lumbar spinal cord sections taken from normal rats and rats with unilateral thoracic dorsolateral funiculus (DLF) lesions. Postoperative survival times ranged from 1 to 28 days. Substance P binding was above normal in laminae 2 and 3 ipsilateral to the lesion and in contralateral lamina 2 at 1 day postoperatively (DPO), and declined thereafter, reaching below normal levels by 28 DPO. Substance P binding in lamina 10 was significantly above normal at 7 and 14 DPO, but not at 1 or 28 DPO. Binding of 5-HT was above normal at 7 DPO in lamina 2 ipsilateral to the lesion, lamina 3 contralaterally, and lamina 10 bilaterally. These increases were not sustained, however, and at 28 DPO 5-HT binding was significantly below normal in laminae 2-4 bilaterally. The bilateral effects seen in the present study are consistent with the bilaterality of descending thoracic DLF projections demonstrated by the Fink-Heimer method.(ABSTRACT TRUNCATED AT 250 WORDS)

Using APA 6th Edition citation style.

[Page generation failure. The bibliography processor requires a browser with Javascript enabled.]

Times viewed: 547

Adding this citation to "My List" will allow you to export this citation in other styles.