Treatment of inflammatory airway disease in young ...
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Citation
| Title | Treatment of inflammatory airway disease in young standardbreds with interferon alpha |
| Author(s) | I. Moore, B. Horney, K. Day, J. Lofstedt, A. Cribb |
| Journal | The Canadian veterinary journal.La revue veterinaire canadienne |
| Date | 2004 |
| Volume | 45 |
| Issue | 7 |
| Start page | 594 |
| End page | 601 |
| Abstract | The effect of oral treatment with natural or recombinant human interferon alpha (HIA) on inflammatory airway disease in young standardbreds was assessed in a double-blind, randomized clinical trial. A total of 34 horses with nasal discharge, excess mucus in the trachea, and a persistent cough of at least 2 weeks' duration that interfered with training completed the trial. Horses were rested for 1 week and received oral treatment with either a saline placebo, recombinant human interferon alpha (rHIA; 90 U/horse/day), or natural human interferon alpha (nHIA: 50 U/horse/day) for 5 days. There was a significant decline in nasal discharge and cough scores in all groups and the apparent response rate was similar. However, significantly fewer horses relapsed within 2 weeks once treatment was ceased when interferon rather than placebo was used (P = 0.012). Seventeen of 22 horses treated with rHIA or nHIA were cough-free 4 weeks after treatment, compared with only 4 of 12 after treatment with the placebo. Treatment with oral interferon is a useful adjunct to rest in standardbreds with inflammatory airway disease. |
| ISSN | 0008-5286 |
Using APA 6th Edition citation style.
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