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Background: Prostate cancer is the most commonly diagnosed form of cancer in men in Canada and the United States. Both genetic and environmental factors contribute to the development and progression of many cancers, including prostate cancer. Context and purpose of this study: This study investigate...
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Prostate cancer is the most commonly diagnosed form of cancer in men in Canada and the United States. Both genetic and environmental factors contribute to development and progression of many cancers, including prostate cancer, with prostate cancer affecting many men worldwide. As such there have bee...
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Oxidative stress has come to the forefront as a contributor to a number of diseases, including cancer, neurodegenerative and cardiovascular diseases (CVD). High-fat diets (HFD) are thought to increase LDL, which can contribute to oxidative stress by becoming oxidized in artery walls, leading to athe...
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Previously we showed that feeding polyphenol-rich wild blueberries (BB) to hypertensive rats lowered systolic blood pressure (BP). Since probiotic bacteria produce secondary metabolites from berry polyphenols which augment the health benefits of berry consumption, we hypothesized that adding probiot...
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Ursolic acid is a constituent of the American cranberry (Vaccinium macrocarpon) and other Vaccinium fruit found primarily in the peel. In this study, the effects of ursolic acid (UA) on the cell cycle behaviour of DU145 human prostate cancer cells in vitro was examined. Following treatment of cells ...
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Constraint induced movement therapy (CIMT), which forces use of the impaired arm following stroke, improves functional recovery. The mechanisms underlying recovery are not well understood, necessitating further investigation into how rehabilitation may affect neuroplasticity using animal models. Ani...
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Abstract: The feeding behavior of algal consumers inhabiting sandy beaches and the consequences of this behavior on their performance are poorly understood. Food quality has been shown to influence the food preference of algal consumers. However, food preference can often be altered or subordinated ...
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Many species' range limits (RL) occur across continuous environmental gradients without obvious barriers imposing them. Such RL are expected to reflect niche limits (NL) and thus to occur where populations cease to be self-sustaining. Transplant experiments comparing fitness within and beyond specie...
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Background The floral development of Dieffenbachia seguine (N. J. Jacquin) Schott is analysed in relation to the molecular phylogeny of the Spathicarpae by Cusimano et al. (Am J Bot 98:654–668, 2011). Results The initiation of discoid floral primordia occurs acropetally on the surface of the sp...
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The supply of planktonic larvae to adult populations is an important contributor to the spatial and temporal variability of benthic marine organisms. The ability to predict spatial patterns of larvae and recruits from the physical and biological processes that facilitate dispersal is required in ord...
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Deficits in attention have long been identified as a core feature in schizophrenia and related neuropsychiatric disorders. We have investigated the combined effects of neonatal treatment with domoic acid (DOM) and social isolation rearing (both putative animal models of schizophrenia) on latent inhi...
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This thesis examines the relationship between fisheries policy, fisheries management, and island community development in Maine and Newfoundland. Three research questions and themes guided this work: 1) what kind of relationship there is between island community development, fisheries policy, and fi...
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Neuropsychiatric disorders affect a significant number of people across the globe and are a serious economic and social burden. As a class of diseases they are often poorly understood, difficult to treat, and can lead to a significant decline in normal function and quality of life. Recent evidence s...
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Youth are an important group within forest communities of Central Africa but can often be underrepresented within traditional decision-making structures. Since youth will be affected by the long term impacts of forest management decisions, they have a large stake in the successful management of reso...
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Freshwater springs are focused discharge points from groundwater to surface water environments. Cool springs have consistent temperatures close to the mean annual temperature for the region and chemical composition that can vary with land use and local geology. Animal taxa inhabiting these springs m...
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This study investigated the effects of magnolol, a compound from Magnolia officinalis, on the behavior of LNCaP and PC3 human prostate cancer cells in vitro. Materials and Methods: In vitro cell culture approach with biochemical tests and Western blot analyses was used. Results: Magnolol, (80 μM, 6...
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Premise of the study: We developed 24 nuclear microsatellite primers from an enriched genomic library for the Pacific coastal dune endemic Camissoniopsis cheiranthifolia to study the consequences of mating system differentiation, the genetics of species' range limits, and hybridization with its clos...
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Background: Prostate cancer, amongst other cancer types has a genetic and environmental component, which can contribute to prostate cancer development and progression. Vaccinum macrocarpon (American cranberry) is a botanical that contains several phytochemicals which have been suggested to play a ro...
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Despite growing concern for biodiversity loss, many coastal areas remain unexplored and their species composition and ecology virtually unknown. This study addressed these issues for intertidal communities of one of the few Atlantic Canada marine protected areas (MPAs). A nested sampling design was ...
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Despite growing concern for biodiversity loss, many coastal areas remain unexplored and their species composition and ecology virtually unknown. This study addressed these issues for intertidal communities of one of the few Atlantic Canada marine protected areas (MPAs). A nested sampling design was ...
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Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds with immunotoxic and carcinogenic potential that may pose a threat to fish populations. The mechanism underlying immune toxicity of PAHs in fishes remains unclear. Some evidence supports the requirement for metabolism to more toxic met...
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