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Allergic diseases are a major medical concern with increasing prevalence in the world. Inflammation is one of the hallmarks of allergic diseases. Long chain n-3 polyunsaturated fatty acids (PUFAs) have been shown to inhibit allergic inflammation, but their direct effect on activation of the mast cel...
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Parasitic sea lice are a major challenge for salmon aquaculture. This is especially due to recent development of resistance to emamectin benzoate (EMB) in the parasite. We investigated 1) whether EMB treatment success in Grand Manan, Bay of Fundy, NB, can be explained through EMB bioassay and P-gp ...
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Control of sea lice, Lepeophtheirus salmonis, on farmed Atlantic salmon, Salmo salar, relies heavily on chemotherapeutants. However, reduced efficacy of many treatments and need for integrated sea lice management plans require innovative strategies. Resistance to emamectin benzoate (EMB), a major se...
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Effective control of parasitic sea lice (including Lepeophtheirus salmonis and Caligus elongatus), is a major challenge currently facing sea cage salmon aquaculture. Emamectin benzoate (EMB; SLICE®), a macrocyclic lactone (ML), has been the drug of choice for sea lice treatment over the past decade...
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Resistance development to parasiticides has been a problem in both terrestrial and aquatic environments. A major challenge exists in early detection of resistance emergence due to the low frequency at which resistant organisms can occur initially within a population and the difficulty in detecting t...
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This chapter covers the host range and specificity, morphology, life cycle, physiopathology, parasite-host interactions, role as disease vector and control and prevention (biological control, environmental approach, drug therapy, vaccination and insecticides) of Lepeophtheirus salmonis and Caligus r...
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Emamectin benzoate (EMB; SLICE®) has been the drug of choice for the control of sea lice in salmon aquaculture within the past decade due to its ease of administration as well as efficacy on all parasitic stages of sea lice. This over-reliance has led to increased tolerance to the drug and a conseq...
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Sea lice (Lepeophtheirus salmonis) are the most economically important ectoparasites affecting Atlantic salmon (Salmo salar) culture worldwide. In recent years the efficacy of historically successful treatments has been on the decline. As such, a new management strategy for controlling lice infectio...
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Zinc homeostasis was studied at the tissue and gill subcellular levels in rainbow trout (Oncorhynchus mykiss) following waterborne and dietary exposures, singly and in combination. Juvenile rainbow trout were exposed to 150 or 600 μg l−1 waterborne Zn, 1500 or 4500 μg g−1 dietary Zn, and a com...
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SUMMARYSome members of the ABC-transporter superfamily, such as P-glycoprotein and the multidrug resistance associated protein, may confer resistance to the avermectin subclass of macrocyclic lactones. The aim of this study was to examine the presence of ABC transporters in both sea lice (Lepeophthe...
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A bioassay for sea lice Lepeophtheirus salmonis sensitivity towards emamectin benzoate (EMB) was validated for field use. A probit regression model with natural responsiveness was used for the number of affected (moribund or dead) sea lice in bioassays involving different concentrations of EMB. Bioa...
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Overexpression of P-glycoproteins (Pgps) is assumed to be a principal mechanism of resistance of nematodes and arthropods to macrocyclic lactones. Quantitative RT-PCR (Q-RT-PCR) was used to demonstrate changes in transcription levels of two putative P-glycoprotein genes, designated here as SL0525 an...
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