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Background: Prostate cancer is the most commonly diagnosed form of cancer in men in Canada and the United States. Both genetic and environmental factors contribute to the development and progression of many cancers, including prostate cancer. Context and purpose of this study: This study investigate...
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Prostate cancer is the most commonly diagnosed form of cancer in men in Canada and the United States. Both genetic and environmental factors contribute to development and progression of many cancers, including prostate cancer, with prostate cancer affecting many men worldwide. As such there have bee...
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Ursolic acid is a constituent of the American cranberry (Vaccinium macrocarpon) and other Vaccinium fruit found primarily in the peel. In this study, the effects of ursolic acid (UA) on the cell cycle behaviour of DU145 human prostate cancer cells in vitro was examined. Following treatment of cells ...
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Wild blueberry extracts were shown to inhibit MMP-2 & MMP-9 activity in DU145 human prostate cancer cells in vitro. This study examined the effects of pterostilbene (PT) on MMP & uPA activities in DU145 cells. PT (30uM)(6h) inhibited MMP-2/-9 activity. PT decreased cellular viability ~10% post 6 h. ...
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This study investigated the effects of magnolol, a compound from Magnolia officinalis, on the behavior of LNCaP and PC3 human prostate cancer cells in vitro. Materials and Methods: In vitro cell culture approach with biochemical tests and Western blot analyses was used. Results: Magnolol, (80 μM, 6...
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Background: Prostate cancer, amongst other cancer types has a genetic and environmental component, which can contribute to prostate cancer development and progression. Vaccinum macrocarpon (American cranberry) is a botanical that contains several phytochemicals which have been suggested to play a ro...
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Background: Prostate cancer is one of the most common cancers in the world. There are genetic and environmental factors that can potentially impact the development and progression of many types of cancer, including prostate cancer. As a consequence of environmental factors, such as diet having a pot...
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Prostate cancer, one of the most common cancers in the Western world, affects many men worldwide. This study investigated the effects of magnolol, a compound found in the roots and bark of the magnolia tree Magnolia officinalis, on the behavior of 2 androgen insensitive human prostate cancer cell li...
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Prostate cancer is one of the most common cancers in the world, and its prevalence is expected to increase appreciably in the coming decades. As such, more research is necessary to understand the etiology, progression and possible preventative measures to delay or to stop the development of this dis...
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Prostate cancer is one of the most common cancers in the Western world, and it is believed that an individual's diet affects his risk of developing cancer. There has been an interest in examining phytochemicals, the secondary metabolites of plants, in order to determine their potential anti-can...
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Oncostatin M (OSM) is a growth and differentiation factor which has been shown to exert both stimulatory and inhibitory effects on tissue invasion in various cell lines. Tissue invasion is a key marker of metastases and can be monitored by examining activities associated with ECM degradation such as...
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Natural 'bioactive' factors have the ability to attenuate atherogenesis in in vitro and in vivo models. The effects of cranberry on the expression of two inflammation-linked enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), were examined in aortic smooth muscle ...
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Blueberry (Vaccinium angustifolium) flavonoid-containing fractions have been shown to inhibit MMP activity (MMP-2/-9) in DU145 prostate cancer cells. This study examined the effect of a whole cranberry extract on MMP activity in DU145 cells. MMP-2/-9 activity was inhibited by this cranberry extract ...
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Regulation of the matrix metalloproteinases (MMPs) is crucial to regulate extracellular matrix (ECM) proteolysis which is important in metastasis. This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP a...
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Proanthocyanidin-rich extracts were prepared by fractionation of the fruit of the North American cranberry (Vaccinium macrocarpon). In vitro growth inhibition assays in eight tumor cell lines showed that selected fractions inhibited the growth of H460 lung tumors, HT-29 colon and K562 leukemia cells...
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Several salt compounds were tested in vitro as inhibitors of Erwinia carotovora subsp. atroseptica (van Hall) Dye (Eca) and Erwinia carotovora subsp. carotovora (Jones) Bergey, Harrison, Breed, Hammer & Huntoon (Ecc), causal agents of bacterial soft rot of potato. All compounds were mixed with p...
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Each year, potato late blight [Phytophthora erythroseptica] and pink rot [PhytolAthora erythroscptica] are responsible for significant postharvest economic losses. Because of restrictions on the use of synthetic fungicides on food, there is Currently a need for less toxic, disease-controlling compou...
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Regulation of the matrix metalloproteinases (MMPs), the major mediators of extracellular matrix (ECM) degradation, is crucial to regulate ECM proteolysis, which is important in metastasis. This study examined the effects of 3 flavonoid-enriched fractions (a crude fraction, an anthocyanin-enriched fr...
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