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Objectives: Methods: Results: Conclusions: The aim of this study was to investigate the feasibility and efficacy of antisense-mediated gene silencing by peptide nucleic acid (PNA) for specific inactivation of the CmeABC multidrug efflux transporter in Campylobacter jejuni.PNA was designed to bind to...
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Human campylobacterosis is one of the most commonly occurring types of bacterial food poisoning in the United States and other developed countries. Most human cases are due to Campylobacter jejuni that is commonly found in the gastrointestinal tract of chickens. The twin-arginine translocase (TAT) s...
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Quorum sensing is a type of bacterial communication mediated by chemical signaling molecules called autoinducers (AIs). The production of AI-2 and AI-3 is dependent on the luxS gene in Escherichia coli O157:H7. A luxS mutation caused a minimal decrease (about 2-fold) in Shiga toxin (Stx) production ...
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Campylobacter jejuni, an important food-borne human pathogen, is increasingly resistant to antimicrobials. Natural transformation is considered to be a main mechanism for mediating the transfer of genetic materials encoding antibiotic resistance determinants in C. jejuni, but direct evidence for thi...
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The article discusses a study by Jiae Yun and colleagues conducted to examine the roles of RpoN in the resistance of Campylobacter jejuni (C. jejuni) under various stress conditions, published in the current issue of the journal. Survivability of an rpoN mutant was compared with the wild-type C. jej...
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Some bacteria can communicate with other species of bacteria by means of autoinducer-2 (AI-2)-mediated quorum sensing. In this study, we demonstrated that AI-2-mediated quorum sensing influences the transcription of flaA, the major flagellin gene in Campylobacter jejuni. A null mutation of luxS in C...
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Campylobacter is a leading foodborne bacterial pathogen, which causes gastroenteritis in humans. This pathogenic organism is increasingly resistant to antibiotics, especially fluoroquinolones and macrolides, which are the most frequently used antimicrobials for the treatment of campylobac...
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Campylobacter jejuni is an important bacterial pathogen causing gastroenteritis in humans. C. jejuni is capable of natural transformation, which is considered a major mechanism mediating horizontal gene transfer and generating genetic diversity. Despite recent efforts to elucidate the transformation...
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CosR (Campylobacter oxidative stress regulator; Cj0355c) is an OmpR-type response regulator essential for the viability of Campylobacter jejuni, a leading foodborne pathogen causing human gastroenteritis worldwide. Despite importance, the function of CosR remains completely unknown mainly because of...
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