Results

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Examined the effects of academic examination stress, on total serum protein (TSP) and patterns obtained in serum protein electrophoresis. TSP and the concentrations and percentages of the major electrophoretically separated serum proteins were measured in 41 healthy biomedical students (aged 19-22 y...
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This review summarizes some of the evidence which implicates an increase in the peripheral and central secretion of pro-inflammatory cytokines in the behavioural changes seen in some stress-induced and brain lesion models of depression. Following a consideration of the role of cytokines in the perip...
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An increased inflammatory response and deficient synthesis of neurotrophic factors (NTFs) may contribute to the etiology of depression. However, the interrelationship between inflammation and NTFs is unknown. Recently, ethyl-eicosapentaenoate (EPA) has been used to treat depression. The mechanism by...
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Monoamine oxidase (MAO) A is a critical enzyme in the catabolism of dopamine. Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder. MAOA gene variation was compared between 234 Chine...
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Examined, in 9 normal volunteers (mean age 33.1 yrs), the in vitro effects of moclobemide on the production of interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?), interferon-? (IFN?), IL-10 and the IL-1 receptor antagonist (IL-1RA) by diluted whole blood stimulated or not with lipopolysaccha...
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No Abstract
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the effect of subacute intracerebroventricular (icv 0.1, 0.5, and 1.0 mg) administration of corticotropin-releasing factor (CRF) for 5 days on behavior, neurotransmitter concentrations, and immune functions was studied in rats / sought to address 2 important questions: (1) do the effects of icv admi...
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Reviews the book, Human Psychoneuroimmunology edited by K. Vedhara and M. Irwin (2005).
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Interleukin (IL)-1beta is a pro-inflammatory cytokine involved in modulating inflammation and stress responses in the brain. Central administration of IL-1beta impairs both memory functions and long-term potentiation (LTP) induction. However, the molecular events responsible for the downstream effec...
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The effects of academic examination stress (AES) on serum concentrations of interleukin (IL)-1 receptor (R) antagonist (A), solubles IL-2R, sIL-6R, soluble glycoprotein 130 (sgp130), Clara cell protein (CC16), sCD8 and sCD14 were evaluated in 38 Ss (ages 19-22). Also examined were relationships amon...
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Reviews 131 studies, published since 1967, to address the effects of olfactory bulbectomy (OB) and drug treatments on immune system, neurotransmitters, and behavior in rats.
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BACKGROUND: Animal studies have demonstrated seasonal changes in immune function mediated by nocturnal melatonin duration as a biological signal for photoperiod. Recent research has highlighted the potential role of neuroimmune dysfunction in depressive disorders. The etiology of winter depression (...
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The bacterial endotoxin lipopolysaccharide (LPS) produces a host of effects in mammals known collectively as 'sickness' behaviours. Acute treatment with LPS also results in a loss of hedonic capacity in rodents that can be measured by changes in responding for reinforcing electrical stimulation of t...
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Previously, we have reported that interleukin-1 beta (IL-1) induces changes in dopaminergic (DA) and serotonergic systems in the core of nucleus accumbens (NAc). We have also demonstrated that n-3 fatty acid ethyl-eicosapentaenoate (EPA) can significantly reduce stress and anxiety-like behaviors, co...
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Thymectomized male rats showed a significant impairment in learning and memory as shown by deficits in passive avoidance and in the Morris water maze test. Following treatment for 20 days with either piracetam or tacrine, the deficit in passive avoidance learning was largely reversed.
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Used the olfactory-bulbectomized rat model of depression to examine relationships between cellular enzyme activities and neutrophil phagocytic response in male rats and to determine how chronic LiCl treatment reverses impaired phagocytic response in neutrophils of the bulbectomized rat.
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Reviews the book, Psychology edited by Miles Hewstone, Frank D. Fincham, and Jonathan Foster (2005).
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Examined the effects of subchronically administered neuropeptide Y (NPY) intracerebroventricular/ly (icv) on behavioral, neurochemical, and immunological parameters in the olfactory bulbectomized (OB) rat model of depression.
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Evidence suggests a link between Parkinson's disease and the dietary intake of omega (n)−3 and n−6 polyunsaturated fatty acids (PUFAs). Presently, we investigated whether an acute dose of parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP+) affects brain n−3 and n−6 PUFA content a...
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Examined the in vitro effects of lithium carbonate on the unstimulated and lipolysaccharide (LPS)?+?phytohemagglutinin (PHA)-induced production of proinflammatory cytokines, such as interleukin-6 (IL-6), IL-8, tumor necrosis factor-? (TNF?) and interferon-? (IFN?), and negative immunoregulatory cyto...
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Interleukin (IL)-1beta may play an important role in Alzheimer's disease. However, the relationships between glucocorticoids and acetylcholine (ACh), and between neurotrophins and ACh in IL-1-induced memory deficits are unknown. While ethyl-eicosapentaenoate (E-EPA) has recently been reported t...
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Hypothalamic paraventricular nucleus (PVN) is one of the main sources of arginine vasopressin (AVP) synthesis and secretion. AVP is the most important bioactive substance in PVN regulating pain process. Our pervious study has pointed that pain stimulation induced AVP increase in the nucleus raphe ma...