Oncostatin M (OM) is a member of the interleukin-6 (IL-6) cytokine subfamily. The binding of OM to its receptor initiates signal transduction through JAK-signal transducers and activators of transcription (STAT) pathways and activates transcription activators through mitogen-activated protein (MAP) ...

BR96 sFv-PE40, a recombinant DNA-derived fusion protein composed of the heavy- and light-chain variable region domains of the monoclonal antibody BR96 and the translocation and catalytic domains of Pseudomonas exotoxin A, is being developed for the treatment of solid tumors expressing cell surface L...

Some 20 male New Zealand White rabbits (five/group) were given either didanosine (ddl) or stavudine (d4T) at 750 and 1500 mg/kg body weight/day by oral intubation for 24 wk. An additional group was given 300 mg/kg body weight/day zidovudine (AZT) as a negative control. After 13 weeks the high dose o...

Cetylpyridinium chloride (CPC) is a quaternary ammonium salt and cationic surfactant. It has been used as a biocide in personal hygiene products and a charge control additive in some reprographic toners. CPC is orally toxic to rats, mice and rabbits and can cause severe eye irritation. Acute inhalat...

Over the past decade, four exotic tunicates (Styela clava, Ciona intestinalis, Botrylloides violaceus and Botryllus schlosseri) have been reported in the Brudenell estuary in Prince Edward Island (PEI), Canada. Styela clava was the first exotic tunicate to arrive in 1997, rapidly establishing, sprea...

With the increasing spread of invasive marine species and their detrimental effects on aquaculture operations globally, mitigation strategies need to be optimized to mitigate economic impacts. The efficacy of a potassium monopersulphonate triple salt based disinfectant used in the aquaculture indust...

Mussel growers in Prince Edward Island (PEI), Canada, currently use high-pressure water spraying (~700 psi) to mortally injure
or dislodge invasive tunicates from mussel product and gear. An added benefit of this process may be the stimulation of byssal
thread production, leading to improv...

The development of effective mitigation techniques against Botryllus schlosseri and Botrylloides violaceus colonizing blue mussel
aquaculture operations has not been well studied. The objectives of our research were to determine the efficacy of using pressurized seawater
in the mitigation ...

Mussel (Mytilus edulis) culture in Atlantic Canada utilizes wild seed harvested from spat collection sites. The economics associated with wild-caught seed have proven to be more favourable than with hatchery-produced seed. This is not, however, the case in all areas. In Washington state, seed used f...

Triploid shellfish are sterile and retain product quality during, and after the spawning period. Field evaluations of diploid and triploid mussels demonstrated that triploids had a greater growth rate than diploids. The growth difference was evident in the first growing year after deployment in a hi...

The induction of triploidy in Mytilus edulis, using 6-dimethylaminopurine (6-DMAP), was investigated as a potential method of providing high quality sterile product in Prince Edward Island (PEI), Canada. Initial results indicated induction by blocking the second polar body would require a treatment ...

The toxicity of BMS-182248, an immunoglobulin (cBR96)-cytotoxic drug (doxorubicin) conjugate, was investigated in Sprague-Dawley rats at single intravenous doses of 508, 1,200, and 2,550 mg/m(2) (conjugated doxorubicin doses of 14.7, 34.8, and 74 mg/m(2), respectively) and compared to that obtained ...