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A description of earlier work that demonstrated that cattle inoculated with a polynucleotide vaccine encoding bovine herpesvirus type 1 (BHV-1) gD are protected from challenge with virulent BHV-1. More recently, a mouse model has been used to identify the main parts of immunomodulation by polynucleo...
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The potential for plasmids encoding a secreted form of bovine herpesvirus type 1 (BHV-1) glycoprotein D (gD) to elicit immune responses in passively immune mice following intramuscular immunization was investigated. In these experiments, 6- to 8-week-old female C3H/HeN or C57BL/6 mice were passively...
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Although intramuscular (i.m.) injection of DNA encoding glycoprotein D (gD) of bovine herpesvirus-1 (BHV-1) induces immune responses in cattle, this route of delivery is inefficient. Here we assessed three parameters that may enhance the efficacy of a gD DNA vaccine in cattle. First, the immune resp...