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The sedative effects of i.m. administration of a low dose of romifidine were evaluated in 13 healthy adult Beagles. Physiological saline solution (0.2 ml), 0.1% romifidine (10, 20, or 40 micro g/kg) or 10% xylazine (1 mg/kg) was given i.m. in a crossover study design. Heart rate, respiratory rate, r...
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The arrhythmogenic effects of anaesthetic drugs were assessed using the arrhythmogenic dose of epinephrine (ADE) model. The purpose of this study was to determine the influence of cholinergic blockade (CB) produced by glycopyrrolate (G) on ADE in 1.5 minimum alveolar concentration (MAC) halothane (H...
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Twenty 3-mmol boluses of LiCl (0.15 mmol/l) were injected IV into healthy Standardbred horses (n=6) at 3-min intervals (60 mmol/horse total dose) during a 1-h period. Blood samples for measurement of serum lithium concentrations were collected before injection and up to 24 h after injection. Behavio...
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Local anesthetic techniques have the unique ability to block peripheral nociceptive input associated with surgical trauma and inflammation and to prevent sensitization of central nociceptive pathways and the development of pathologic pain. Complete neural blockade of the canine brachial plexus is di...
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Managing perioperative pain effectively is one the most important tasks that clinical veterinarians perform on a daily basis. The purpose of this article is to provide veterinarians with a basic understanding of the pathophysiology of perioperative pain and a working knowledge of the principles of e...
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Many perioperative pain management protocols for cats and dogs are overly complex, some are ineffective, and still others expose patients to unnecessary risk. The purpose of this article is to provide clinicians with a basic understanding of the pathophysiology of perioperative pain and a working kn...
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In a series of trials at least 3 days apart, dogs (12.5 to 21.5 kg) were assigned at random to each of 6 groups: halothane-saline (HS), halothane-xylazine (HX), halothane-medetomidine (HM) and the corresponding groups with glycopyrrolate (HGS, HGX, HGM). Dogs were anaesthetized with halothane (1.31%...
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