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288 mice were divided into four groups and exposed to aerosols of P. haemolytica or S. aureus in four replicates. The numbers of bacteria were determined in the trachea and lungs of mice killed 0, 2, 4, 8, 12, 24, 48 and 72 hours after exposure. Bacterial deposition was greater in lungs than in trac...
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The relationship between acute pulmonary cell injury and inflammatory response was investigated in rats killed 1, 3, and 7 days after tracheal inoculation with bacterial lipopolysaccharide (LPS). Inoculation with LPS induced an influx of polymorphonuclear leukocytes (PMN) and a mild increase in pulm...
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One of the major target organs of hydrogen sulphide gas is the lung. Exfoliation of upper respiratory epithelia and pulmonary edema are prominent effects. Various neuropeptides contained in afferent C-fibres are intimately associated with the epithelia of the conducting airways and are liberated upo...
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Three, 5 or 7 days after inoculation with bovine viral diarrhea (BVD) virus (n = 12) or Mycoplasma bovis (n = 12), groups of calves were exposed to aerosols of Pasteurella haemolytica and were euthanatized 44 hours later. Histologic lesions in the lungs and the ratios of neutrophils to alveolar macr...
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A 3 1/2 -month-old pub with oculonasal discharge and seizures was submitted for postmortem examination. Grossly, the lungs had cranioventral consolidation, and microscopically, 2 distinct types of inclusion bodies compatible with Canine distemper virus and Canine adenovirus type 2. Presence of both ...
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38 Wistar rats with a mean weight of 177 g were divided in 5 groups. Rats were inoculated i.t. with 0.5 ml of fluid (made up to a constant volume using saline solution) containing 2.5 mg of silica, but a variable amount of amniotic fluid (0, 0.125, 0.250, 0.375 or 0.500 ml). The rats were killed 72 ...
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Meconium staining of the skin is a common event associated with fetal hypoxia, stillbirths, weak-born piglets, and neonatal mortality. Aspiration of meconium leads to meconium aspiration syndrome (MAS). This study was undertaken to assess the relationship between the degree of meconium staining of t...
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The aim of this investigation was to do a comparative study on the deposition and clearance of inhaled bacteria between the lungs and tracheae of mice exposed to aerosols of bacteria. Mice were divided into 4 groups of 72 each and exposed to aerosols of P. haemolytica or S. aureus in 4 replicates. T...
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An outbreak of bovine rabies occurred on a ranch when cattle were bitten by vampire bats. Microscopic lesions showed a nonsuppurative encephalitis with intracytoplasmic inclusion bodies. Immunohistochemistry demonstrated viral antigen in the brain, and monoclonal antibodies identified a serotype 1 (...
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Multiple congenital anomalies were identified in a stillborn calf, including severe cerebellar hypoplasia and central nervous system abnormalities resembling the Arnold-Chiari syndrome of malformation of calves. The Arnold-Chiari malformation occurs sporadically and has little economic impact, where...
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Considering the poor facilities available for microbiologic diagnosis in some countries where B. abortus is a frequent cause of bovine abortion, a study was conducted to determine if isolation of B. abortus from an aborted bovine fetus could be predicted from a detailed histological study of the for...
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Fischer-344 rats were killed by exsanguination 1, 20, and 44 hr after a single 4-hr exposure to an atmosphere of 0, 10, 200, and 400 ppm of hydrogen sulfide (H2S). Alterations in the activities of lactate dehydrogenase and alkaline phosphatase, and cytomorphology of epithelial cells in fluids obtain...
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Histology and immunohistochemistry were used to analyse the lesions and distribution of Mycoplasma bovis antigen in the lungs of 18 naturally infected calves. Microscopic examination of pneumonic lungs revealed two distinct patterns of necrosis and inflammation. The first pattern was observed in six...
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"Meconium aspiration syndrome" is a condition resulting in respiratory distress and the occasional death of newborn human beings. A retrospective study was conducted on 52 calves that were submitted for postmortem examination to the Atlantic Veterinary College, Charlottetown, Prince Edward...