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We present a new method for extracting the effective attenuation coefficient and the diffusion coefficient from relative spectrally resolved cw radiance measurements using the diffusion approximation. The method is validated on both simulated and experimental radiance data sets using Intralipid-1% a...
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We have applied an interstitial radiance-based technique based on a spectro-angular mapping approach to the identification and angular localization of 250-nm and 5-nm Au nanoparticle-based inclusions and non-scattering (water only) inclusions in the Intralipid-1% liquid phantom. A combination of the...
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Detection of non-scattering domains (voids) is an area of active research in biomedical optics. To avoid complexities of image reconstruction algorithms and requirements of a priori knowledge of void locations inherent to diffuse optical tomography (DOT), it would be useful to establish specific exp...
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Background: We have developed a new approach to map localized inclusions of gold nanoparticles in the Intralipid-1% liquid phantom. Our goal was to show that combined spectroscopic and angular snapshots of liquid phantoms and phantoms with inclusions allow obtaining information relevant for prostate...
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We present a new approach to the analysis of radiance in turbid media. The approach combines data from spectral, angular and spatial domains in a form of spectro-angular maps. Mapping provides a unique way to visualize details of light distribution in turbid media and allows tracking changes with di...
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Interstitial fiber-optic based strategies for therapy monitoring and assessment rely on detecting treatment-induced changes in the light distribution in biological tissues. We present an optical technique to identify spectrally and spatially specific tissue chromophores in highly scattering turbid m...
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We analyze a role of a localized inclusion as a probe for spatial distributions of migrating photons in turbid media. We present new experimental data and two-dimensional analysis of radiance detection of a localized absorptive inclusion formed by gold nanoparticles in Intralipid-1% when the target ...
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We demonstrated the application of relative radiance-based continuous wave (cw) measurements for recovering absorption and scattering properties (the effective attenuation coefficient, the diffusion coefficient, the absorption coefficient and the reduced scattering coefficient) of bulk porcine muscl...
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One of the major limitations of the use of optoacoustics (OA) for the imaging of prostate cancer is the relatively low resolution when performed in real time. The work presented in this thesis aims to address this limitation by applying frequency-based analyses, which contribute additional informati...
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The interferometric measurement of laser induced thermoelastic expansion of tissue samples can be used to estimate their optical, thermal and mechanical properties. This method was used to assess the Gruneisen coefficient and optical attenuation depth for native and coagulated ex-vivo bovine liver a...
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Laser thermal therapy involves heating tissue using light to temperatures between 55 °C and 95 °C for several minutes resulting in coagulation and cell death. This treatment method has been under investigation for use as a minimally invasive method for treating solid tumors and cancer cells. Heati...
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Optoacoustic imaging is being investigated as a potential tool for monitoring the onset and progression of laser thermal therapy. In this study OA images were acquired from ex vivo bovine liver using a reverse-mode OA imaging system consisting of a pulsed laser operating at 775 nm, and an 8 element ...
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Motivated by a recent report by Dickey et al. [Phys. Med. Biol. 46, 2359 (2001)], who demonstrated optical property retrieval by using relative radiance measurements at a single position, we investigate the uniqueness of relative radiance measurements for quantifying the optical properties of turbid...
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Background and Objectives: Fluoroptic sensors are used to measure interstitial temperatures but their utility for monitoring laser interstitial thermal therapy (LITT) is unclear because these sensors exhibit a measurement artefact when exposed to the near-infrared (NIR) treatment light. This study i...
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Interstitial quantification of the optical properties of tissue is important in biomedicine for both treatment planning of minimally invasive laser therapies and optical spectroscopic characterization of tissues, for example, prostate cancer. In a previous study, we analyzed a method first demonstra...
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Multipoint optical fluence measurements can potentially be used to detect coagulation-induced changes in optical propagation during interstitial laser thermal therapy. Estimating the dimensions of coagulation using on-line optical monitoring, which is applicable to treatments where the tip of the so...
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Background and Objective: Interstitial Laser Photocoagulation (ILP) is a minimally invasive cancer treatment technique, whereby optical energy from implanted optical fibers is used to therapeutically heat small, solid tumors. In this work, the potential of ILP without tissue charring is investigated...
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A novel optoacoustic phantom made of polyvinyl chloride-plastisol (PVCP) for optoacoustic studies is described. The optical and acoustic properties of PVCP were measured. Titanium dioxide (TiO2) powder and black plastic colour (BPC) were used to introduce scattering and absorption, respectively, in ...
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Laser thermal therapy uses near-infrared optical energy to heat and thereby treat diseased tissues such as solid tumors. A method to monitor the progress of laser thermal therapy by detecting temperature-induced changes in optical propagation has been developed. The advantage of a point optical moni...