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Preliminary evidence shows that ethyl-eicosapentaenoate (E-EPA) has a marked clinical effect when used as an adjunct in therapy-refractory depression. EPA belongs to the class of polyunsaturated omega-3 fatty acids. The mechanism of its action in depression is not fully understood. There are two rel...
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Proinflammatory cytokine interleukin (IL)-1beta can cause cognitive impairment, activate the hypothalamic-pituitary-adrenal axis and impair monoaminergic neurotransmission in the rat. IL-1beta has also been shown to increase the concentration of the inflammatory mediator prostaglandin E2 (PGE2) in t...
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Our previous study has pointed that arginine vasopressin (AVP) and norepinephrine (NA) are two most important bioactive substances that play a role in hypothalamic paraventricular nucleus (PVN) regulating pain process. The communication was designed to investigate the interaction between AVP and NA ...
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Determined leucocyte adhesiveness/aggregation (LAA) during stress in 44 rats following sham operation or olfactory bulbectomy. The effects of chronic treatment with the antidepressant desipramine and calf thymopeptides on the LAA state and differential white cell count were also assessed. In the olf...
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BACKGROUND: An increase in inflammatory response and an imbalance between T-helper (Th) 1 and 2 functions have been implicated in major depression. The aims of the present study were to 1) study the relationship between pro- and anti-inflammatory cytokines and between Th1 and Th2 produced cytokines ...
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Background The n-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA) has been found to process neuroprotective effects. However, the exact cellular mechanisms are not well understood. Brain-derived neurotrophic factor (BDNF) is one of neurotrophins, which is involved in neuron differentiation,...
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Examined (1) the activity of serum prolyl endopeptidase (PEP) and dipeptidlyl peptidase IV (DPP IV) in 12 detoxified alcohol-dependent patients without liver disease vs 12 normal controls, and (2) the relationships between serum DPP IV and PEP activity and the production of cytokines or cytokine rec...
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Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1? can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone. The present experiment provides independent confirmation that intracerebroventricular administration o...
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Examined the effects of chronic treatment with non-sedative histamine H-sub-1 receptor antagonist terfenadine on the behavioral and immunological parameters in the olfactory bulbectomized (OB) rat model of depression. OB Sprague-Dawley rats were injected with saline or terfenadine for 16 days after ...
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Examined the concentrations of immunoglobulin IgM, complement C3c, complement C4, positive acute phase proteins (e.g., haptoglobin, ?-sub-1-acid glycoprotein, ?-sub-1-antitrypsin), and negative acute phase proteins (e.g., albumin, transferrin) in 20 unipolar depressed patients and 8 healthy controls...
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Examined the effect of 2 neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; 100 ?g/kg) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Male Sprague-Dawley rats were used in 2 studies. Both puff and restr...
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Examined the effects of the chronic administration of the sigma ligand JO 1784 (igmesine) CRF-induced changes in some behavioural, immune, endocrine and neurotransmitter parameters in rats.
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Examined the effects of psychological stress on platelet ?2-adrenergic receptor (?2-AR) binding sites in relation to stress-induced anxiety and changes in the inflammatory response system.
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Examined the effects of academic examination stress on leukocyte and lymphocyte subset distribution in university students.
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Investigated the effects of chronic treatment with serotonin (5-hydroxytryptamine [5-HT]) reuptake inhibitors, fluvoxamine (FL) and sertraline (SE) for 20 days on the behavior, neurotransmitter concentrations, and immune functions in the olfactory bulbectomized rat model of depression. Ss were adult...
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Examined the production of interferon-?, tumor necrosis factor-? (TNF-?), granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6 (IL-6), IL-10, IL-4, IL-5, IL-1 receptor antagonist (IL-IRA), and prostaglandin E-sub-2 in relation to the number of leukocytes in the blood of detoxifie...
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Assessed the effect of chronic (3 mmol/kg for 15 days) lithium chloride (Li) on open field activity and immune function in bilaterally olfactory bulbectomized and sham-operated male rats. Li did not reverse the hyperactivity of the bulbectomized rats (BRs) and did not affect growth rate significantl...
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Examined the effects of academic examination stress, on total serum protein (TSP) and patterns obtained in serum protein electrophoresis. TSP and the concentrations and percentages of the major electrophoretically separated serum proteins were measured in 41 healthy biomedical students (aged 19-22 y...
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This review summarizes some of the evidence which implicates an increase in the peripheral and central secretion of pro-inflammatory cytokines in the behavioural changes seen in some stress-induced and brain lesion models of depression. Following a consideration of the role of cytokines in the perip...
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An increased inflammatory response and deficient synthesis of neurotrophic factors (NTFs) may contribute to the etiology of depression. However, the interrelationship between inflammation and NTFs is unknown. Recently, ethyl-eicosapentaenoate (EPA) has been used to treat depression. The mechanism by...
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Monoamine oxidase (MAO) A is a critical enzyme in the catabolism of dopamine. Dysfunction of dopaminergic systems has been implicated in the pathophysiology of schizophrenia, suggesting that MAOA gene variation might be associated with the disorder. MAOA gene variation was compared between 234 Chine...